dc.contributor.author | Jeon, Chanil | |
dc.contributor.author | Jung, Youngkyun | |
dc.contributor.author | Ha, Bae-Yeun | |
dc.date.accessioned | 2017-11-07 16:22:19 (GMT) | |
dc.date.available | 2017-11-07 16:22:19 (GMT) | |
dc.date.issued | 2016-10-25 | |
dc.identifier.uri | http://dx.doi.org/10.1039/c6sm01184e | |
dc.identifier.uri | http://hdl.handle.net/10012/12615 | |
dc.description.abstract | A chain molecule can be entropically collapsed in a crowded medium in a free or confined space. Here, we present a unified view of how molecular crowding collapses a flexible polymer in three distinct spaces: free, cylindrical, and (two-dimensional) slit-like. Despite their seeming disparities, a few general features characterize all these cases, even though the phi(c)-dependence of chain compaction differs between the two cases: a > a(c) and a < a(c), where phi(c) is the volume fraction of crowders, a is the monomer size, and ac is the crowder size. For a > a(c) (applicable to a coarse-grained model of bacterial chromosomes), chain size depends on the ratio a phi(c)/a(c), and "full'' compaction occurs universally at a phi(c)/a(c) approximate to 1; for a(c) > a (relevant for protein folding), it is controlled by phi(c) alone and crowding has a modest effect on chain size in a cellular environment (phi(c) approximate to 0.3). Also for a typical parameter range of biological relevance, molecular crowding can be viewed as effectively reducing the solvent quality, independent of confinement. | en |
dc.description.sponsorship | NSERC (Canada) | en |
dc.description.sponsorship | Korea Institute of Science and Technology Information (KISTI) | en |
dc.description.sponsorship | Basic Science Research Program [2015R1D1A1A09057469] | en |
dc.description.sponsorship | KIAS (Korea Institute for Advanced Study) | en |
dc.language.iso | en | en |
dc.publisher | Royal Society of Chemistry | en |
dc.subject | Escherichia-Coli Chromosome | en |
dc.subject | Dynamics Simulation | en |
dc.subject | Polymer-Chains | en |
dc.subject | Poor Solvents | en |
dc.subject | Condensation | en |
dc.subject | Collapse | en |
dc.subject | Model | en |
dc.subject | Macromolecules | en |
dc.subject | Consequences | en |
dc.subject | Environments | en |
dc.title | Effects of molecular crowding and confinement on the spatial organization of a biopolymer | en |
dc.type | Article | en |
dcterms.bibliographicCitation | Jeon, C., Jung, Y., & Ha, B.-Y. (2016). Effects of molecular crowding and confinement on the spatial organization of a biopolymer. Soft Matter, 12(47), 9436–9450. https://doi.org/10.1039/C6SM01184E | en |
uws.contributor.affiliation1 | Faculty of Science | en |
uws.contributor.affiliation2 | Physics and Astronomy | en |
uws.typeOfResource | Text | en |
uws.peerReviewStatus | Reviewed | en |
uws.scholarLevel | Faculty | en |