Browsing Theses by Author "Vigna, Christopher"
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Hsp70 Protects Against Peroxynitrite-Induced Inactivation of SERCA2a by Preventing Protein Oxidation and Aggregation
Vigna, Christopher (University of Waterloo, 2008-09-18)The purpose of this study was to examine the effects of exogenous peroxynitrite (ONOO-) on the cardiac isoform of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a) and to determine if overexpression of heat shock ... -
NADPH Oxidase-dependent ROS Production and Impaired Ca2+ Regulation are Associated with Exercise-induced Cardiac Fatigue in the Rat
Vigna, Christopher (University of Waterloo, 2015-12-10)Cardiac fatigue is a phenomenon that is characterized by a transient reduction in left ventricular contractile and/or relaxation function following acute aerobic exercise. Few studies have utilized rodent models to examine ...