Browsing Theses by Subject "obesity"
Now showing items 1-20 of 21
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Anti-obesity public health vs. fat acceptance: impacts on 'fat' as a marginalized identity
(University of Waterloo, 2020-09-10)I will argue that anti-obesity public health (AOPH), with a focus on Canadian AOPH, performs three functions with respect to the fat acceptance movements (FAMs). These are as follows. Firstly, AOPH distracts by derailing ... -
An Assessment of Pyridoxine as a Biological Response Modifier During Colon Carcinogenesis
(University of Waterloo, 2007-10-05)The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon ... -
Assessment of the cell cycle proteins Cdc7 and PCNA as markers of colon carcinogenesis in obese and lean rats
(University of Waterloo, 2009-11-23)Obesity increases the risk of colon cancer as well as the expression of many cancer markers, ostensibly due to the interaction between insulin resistance and adipocyte production of hormones, mitogens and cytokines which ... -
Body Mass Index and Missing Data: Examining the Levels, Patterns, and Impacts of Missing Data in a Large Cohort Study of Canadian Youth
(University of Waterloo, 2022-12-19)Missing data are generally unavoidable in survey-based research. Small amounts of random missingness may not pose significant problems; however, issues arise when data are missing in large proportions or when missingness ... -
Comparing occupational musculoskeletal exposures during common materials handling tasks between non-obese and obese adults
(University of Waterloo, 2017-12-08)Higher body mass is associated with increased risk of musculoskeletal injury, a greater number of insurance claims, and higher direct and indirect costs due to decreased productivity during manual materials handling. Over ... -
A Diet High in Saturated Fat Leads to Obesity in Female Rats, but Does Not Affect Total, Synaptic, or Cell Surface Expression of NMDA Receptor Subunits In Hippocampus
(University of Waterloo, 2013-06-20)Obesity is an accumulation of adipose tissue to the point of negative health outcomes; the association of obesity with type 2 diabetes and cardiovascular disease is particularly profound. Notably, obesity has begun to be ... -
Does a High-Fat Diet Cause Inflammation in Female Rat Brain?
(University of Waterloo, 2015-08-12)Obesity results from a disruption of normal energy homeostasis, and leads to a state of chronic low-grade inflammation. Given that inflammatory cytokines can disrupt synaptic activity and that obesity has been shown to ... -
Does maternal obesity affect hippocampal-dependent spatial learning and memory retention in offspring?
(University of Waterloo, 2015-10-02)With a rise in the prevalence of obesity worldwide, behavioural, as well as physiological changes after consumption of a high-fat diet are becoming increasingly recognized. In addition to increased risk of chronic and ... -
The Effects of Body Mass Index and Gender on Pelvic Stiffness and Peak Impact Force During Lateral Falls
(University of Waterloo, 2011-09-28)Fall-related hip fractures are a substantial public health issue. Unfortunately, little is known about whether the effective stiffness of the pelvis, a critical component governing impact force during lateral falls, differs ... -
Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice
(University of Waterloo, 2010-08-26)Type II diabetes mellitus (T2DM) has been associated with the onset of diet-induced obesity, which is currently on the rise worldwide. T2DM is typically characterized by insulin resistance in peripheral tissues such as ... -
Examining the bidirectional associations between adiposity and cognitive function using population-level data
(University of Waterloo, 2022-08-19)Background: The association between adiposity and cognitive function has been extensively explored in previous literature, and numerous cross-sectional and longitudinal analyses suggest a reliable association. However, ... -
Gender Differences in Chronic Disease Risk Behaviours and their Association with Body Mass Index: Cross-sectional and Longitudinal Multilevel Analyses Among a Large Sample of Youth.
(University of Waterloo, 2019-08-20)Obesity has become a worldwide concern due to the escalating number of individuals who have overweight or obesity. The prevalence of overweight/obesity among youth aged 12-17 years old was 37% in 2012-2013, as reported in ... -
Glucose Metabolism in High-Risk Prostate Cancer Patients throughout the Acute Disease Trajectory
(University of Waterloo, 2016-05-16)Background: Hyperglycemia and insulin resistance are associated with obesity, physical inactivity, and poor diet, and may be related to hyperinsulinemia, disrupted lipid and adipokine signaling, and pro-inflammation. The ... -
The ignored consequences of obesity and nutrition policies: How a focus on weight influences psychosocial wellbeing
(University of Waterloo, 2020-08-12)Background: Eating- and weight-related disorders, including eating disorders, disordered eating, and overweight and obesity, share many risk factors across all levels of the socioecological model. However, public health ... -
IN VIVO EPIGENETIC STUDY OF HISTONE ACETYLATION ASSOCIATED WITH OBESITY
(University of Waterloo, 2007-10-02)Post translational modifications in histone proteins are transmissible changes that are not coded for in the DNA sequence itself but have a significant affect in the control of gene expression. Eukaryotic transcription is ... -
Mathematical Modelling of Social Factors in Decision Making Processes at the Individual and Population Levels
(University of Waterloo, 2016-08-11)In this thesis we apply mathematical modelling techniques to investigate the implications of social influence on decision making processes in two related contexts. The first problem concerns the mathematical modelling ... -
Obesity associated colon tumorigenesis: An assessment of tumor phenotype
(University of Waterloo, 2006)Colon cancer and obesity are two significant and related pathological states with multiple etiological factors. In this dissertation, it was hypothesized that tumor growth is accelerated in the altered state of obesity ... -
Obesity, Physical Activity and Sedentary Behaviour Among Canadian First Nations Youth: An Exploration of Associated Factors and Evaluation of a School Sports Program
(University of Waterloo, 2016-01-19)Background: Secondary to inequities in several determinants of health, Canadian Aboriginal youth are affected by a higher prevalence rate of obesity and chronic disease than the general population. While the factors ... -
Predicting Overweight and Obesity Among Youth in Ontario, Canada: Evidence from Cross-sectional and Longitudinal Analyses
(University of Waterloo, 2017-09-13)The percentage of Canadian children and adolescents that are overweight or obese has increased dramatically since the 1980s, with approximately 25% of youth in Canada now characterised as overweight or obese. Canadian youth ... -
Protection against high fat diet induced obesity in mdx mice: is sarcolipin involved?
(University of Waterloo, 2018-02-15)Sarcolipin (SLN) is a 31 amino acid proteolipid and one of the regulators of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps. Previous research has shown that sarcolipin levels in muscles from wild type (WT) mice ...