Browsing Theses by Supervisor "Campbell, Melanie"
Now showing items 1-7 of 7
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Morphological and Multifractal Analyses of Retinal Amyloid Deposits for Staging in Alzheimer's Disease
(University of Waterloo, 2020-02-12)Dementia is a neurodegenerative condition that leads to loss of cognitive ability, typically in older adults. Alzheimer's disease (AD) is the most common cause of dementia and affects millions of people worldwide. The ... -
Mueller Matrix Confocal Scanning Laser Polarimetry and Optimal Conditions for Improved Image Quality
(University of Waterloo, 2021-01-26)Alzheimer's disease (AD), a fatal neurodegenerative disorder, is the most common form of senile dementia. Five hundred thousand Canadians are living with dementia, a number predicted to double by 2030. Currently, the most ... -
Optical aberrations and cone photoreceptor sampling during normal emmetropization and emmetropization to imposed defocus
(University of Waterloo, 2018-04-23)The eye grows in a coordinated fashion during normal emmetropization which results in an image close to being in focus on the retina for distance vision. Myopia results from the failure of normal emmetropization. Myopia ... -
Polarimetric and birefringence analysis of presumed amyloid-beta deposits in the retina in association with Alzheimer's disease
(University of Waterloo, 2018-09-26)Alzheimer's disease is a neurodegenerative disease which leads to symptoms such as loss of memory and other neurological dysfunctions, ultimately leading to death. Two key hallmarks of Alzheimer's disease are abnormally ... -
Predicting the thioflavin fluorescence of retinal amyloid deposits in association with Alzheimer’s disease and differentiating amyloid protein from alpha-syn
(University of Waterloo, 2020-09-02)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia. According to the World Health Organization (WHO) in 2019, dementia affects around 50 million people worldwide and this number ... -
Proposed Methods For Measuring and Interpreting Mueller Matrices in In Vivo Retinal Polarimetry
(University of Waterloo, 2020-12-23)Mueller matrix polarimetry is the examination of how a sample transforms the polarization state of light. This requires probing the sample with input light of a variety of generated polarization states and analyzing the ... -
Wavefront assessment and correction of the rat eye for two photon excitation therapies
(University of Waterloo, 2016-08-31)Photodynamic therapy (PDT) is a treatment in which light excites a photosensitive drug to produce oxygen radicals that kills nearby cells. Today, PDT’s is most commonly used application is for the destruction of cancerous ...