Browsing Theses by Supervisor "Kohandel, Mohammad"
Now showing items 1-8 of 8
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Advancing Antibody Design: Integrating Protein Language Models for Enhanced Computational Strategies
(University of Waterloo, 2024-01-25)Antibodies, or immunoglobulins, are integral to the immune response, playing a crucial role in recognizing and neutralizing external threats such as pathogens. The design of these molecules, however, is complex due to the ... -
Applications of Deep Learning to Differential Equation Models in Oncology
(University of Waterloo, 2023-07-25)The integration of quantitative tools in biology and medicine has led to many groundbreaking advances in recent history, with many more promising discoveries on the horizon. Conventional mathematical models, particularly ... -
Evolutionary Dynamics of Cancer: Spatial and Heterogeneous Effects
(University of Waterloo, 2017-01-23)Despite significant advances in the study of cancer and associated combination therapeutic treatments, cancer still remains one of the most common and complex often-terminal diseases. Acquisition of high-throughput ... -
Integrating Experimental and Computational Approaches to Optimize 3D Bioprinting of Cancer Cells
(University of Waterloo, 2023-08-21)A key feature distinguishing 3D bioprinting from other 3D cell culture techniques is its precise control over created structures. This property allows for the high-resolution fabrication of biomimetic structures with ... -
Machine Learning Techniques and Stochastic Modeling in Mathematical Oncology
(University of Waterloo, 2022-07-18)The cancer stem cell hypothesis claims that tumor growth and progression are driven by a (typically) small niche of the total cancer cell population called cancer stem cells (CSCs). These CSCs can go through symmetric ... -
Mathematical approaches to the study of cellular heterogeneity, treatment design, and immune response in cancer
(University of Waterloo, 2020-01-09)One of the complicating factors in treating cancer patients is the different levels of heterogeneity involved. In this thesis, we use a combination of mathematical methods (in silico experiments) and experimental data (in ... -
Mathematical Modelling of Cancer Treatments Involving Radiation Therapy and Hypoxia-Activated Prodrugs
(University of Waterloo, 2019-08-19)Cancer is one of the world's deadliest diseases despite immense investments into oncological research in recent years. Although great strides have been made in our understanding of cancer, much remains unknown regarding ... -
Studies of tumor heterogeneity, tumor microenvironment, and radiotherapy: A mathematical and computational approach
(University of Waterloo, 2019-01-04)Radiotherapy uses high doses of energy to eradicate cancer cells and thus destroy the bulk of tumors. Radiobiologists try to precisely deliver radiation to a targeted area in order to maximize the cancer cell kill rate ...