Browsing Science (Faculty of) by Author "Ma, Lingzi"
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Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology
Ma, Lingzi; Liu, Juewen (Elsevier, 2020-01)Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been used in different areas. Compared with protein enzymes, catalytic nucleic acids are programmable in structure, easy to modify, ... -
DNA Adsorption by ZnO Nanoparticles near Its Solubility Limit: Implications for DNA Fluorescence Quenching and DNAzyme Activity Assays
Ma, Lingzi; Liu, Biwu; Huang, Po-Jung Jimmy; Zhang, Xu; Liu, Juewen (American Chemical Society, 2016-06-07)Zinc oxide (ZnO) is a highly important material, and Zn2+ is a key metal ion in biology. ZnO and Zn2+ interconvert via dissolution and hydrolysis/condensation. In this work, we explore their interactions with DNA, which ... -
In Vitro Selection, Characterization, and Application of a Sodium-Dependent DNAzyme and a Metal-Independent Ribozyme
Ma, Lingzi (University of Waterloo, 2021-09-20)Ribozymes and DNAzymes are collectively called catalytic nucleic acids. Compared to protein enzymes, catalytic nucleic acids are programmable in structure, easy to synthesize or modify, and more chemically stable especially ... -
A New Na(+)-specific DNAzyme Mutant from in Vitro Selection
Ma, Lingzi (University of Waterloo, 2017-09-08)Sodium is one of the most ubiquitous metal ions in both intracellular and extracellular fluids. Many fluorescent sensors have been designed to measure Na+ concentrations. However, Na+ binding to biomolecules such as DNA ...