Browsing Science (Faculty of) by Supervisor "Leonenko, Zoya"
Now showing items 1-6 of 6
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Antimicrobial Peptide Daptomycin and its Inhibition by Pulmonary Surfactant: Biophysical Studies using Model Membrane Systems
(University of Waterloo, 2017-04-25)Daptomycin is a lipopeptide antibiotic that is clinically used to treat severe infections caused by Gram-positive bacteria. It is highly potent against resistant strains of bacteria such as methicillin-resistant Staphylococcus ... -
The Compared Effects of Lithium Isotopes ⁶Li and ⁷Li on GSK-3-β Activity and the Biochemistry of HT22 Neuronal Cells
(University of Waterloo, 2020-12-09)The use of lithium in treatment of mental illnesses like bipolar disorder, major depressive disorder, and schizophrenia dates to the mid 20th century. Some research also indicates that the symptoms of Alzheimer’s Disease ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Nanoscale physics of surfactant gene delivery
(University of Waterloo, 2016-01-18)Medicine has met a revolution in the expansion of possibilities for therapy based upon synthetic gene delivery. Imagine the ability to correct problems of a genetic origin with a simple drug -- such science fiction fantasies ... -
A preclinical study of SG pseudopeptide amyloid-β inhibitors for the treatment of Alzheimer’s disease: single molecule force spectroscopy and cell viability
(University of Waterloo, 2017-08-23)Alzheimer's disease (AD) is one of the single greatest healthcare challenges facing our society today with no treatments available that cure, prevent or slow the disease. Neurodegeneration in AD is observed alongside ... -
The Role of Melatonin in Amyloid Interactions with the Model Neuronal Membranes
(University of Waterloo, 2023-11-29)The amyloid cascade hypothesis has long directed research efforts in understanding the pathogenesis of Alzheimer’s disease (AD), ever since it was first proposed through clinical evidence by Hardy and Higgins in 1992. ...